PLENADREN

Reason for request

Clinical Benefit

Substantial

The actual benefit of PLENADREN is substantial.

Clinical Added Value

minor

The PLENADREN modified-release dosage form of hydrocortisone is closer to the pharmacokinetic profile of the physiological rhythm of cortisol, without any clinical consequence having been demonstrated. Consequently, PLENADREN provides a minor improvement in actual benefit (IAB IV) in the care of patients with adrenal insufficiency.