GLUCOSE COOPER 5% (glucose), glucose infusion

NUTRITION & INTENSIVE CARE - Update
Opinions on drugs - Posted on May 10 2017

Reason for request

Renewal of inclusion

In paediatrics, no clinical benefit from a hypotonic glucose solution for injection outside its use as a vehicle for infusion therapy, because of the risk of severe or fatal hyponatraemia.

  

  • Glucose-based medicinal products administered by injection have marketing authorisation:

      - as rehydration treatment when water loss is greater than loss of sodium chloride loss and other osmoles;

      - for the prevention of intra- and extracellular dehydration;

      - in the treatment and prevention of ketosis in undernourishment;

      - as a vehicle for administering therapies in the preoperative, perioperative and immediate postoperative period.

  •  The main benefit of a (hypotonic) 5% glucose solution for injection is its use as a vehicle for infusions of injectable medicinal products.
  • Hypotonic glucose solutions should be avoided in paediatrics to prevent encephalopathy caused by dilutional hyponatraemia.

 

 


Clinical Benefit

Substantial

-


Therapeutic use

-

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